University of Alberta researchers have created a new tool to help doctors and patients recognize other illnesses commonly associated with inflammatory bowel disease (IBD), including autoimmune, mental health and heart problems. The team used artificial intelligence to analyze de-identified medical records for 30,334 Albertans living with inflammatory bowel disease over a 20-year period.

They report that 57 per cent of patients have at least one other associated autoimmune disorder or manifestation of disease beyond the gut. Mental and musculoskeletal disorders are the most common, but they also found elevated incidences of dermatological and respiratory conditions, disorders of the genitals and urinary system, and cardiovascular disease. Using a new approach known as network medicine, the team created interactive tools to visualize the occurrence, frequency, sequence and clustering of the associated disorders as an aid for diagnosing and treating conditions that may otherwise be overlooked.

The takeaway for the patient is that while they may be seeing a gastroenterologist with expertise in inflammatory bowel disease because they experience diarrhea, rectal bleeding or abdominal pain, it may turn out that they actually have several other conditions as well, says principal investigator Daniel C. Baumgart, professor of medicine and adjunct professor of computing science.

Physicians will want to ensure that patients are managed by a multidisciplinary team, and the tools help to find out which other conditions to actively screen for, says Baumgart, who is also principal investigator and program director of From Data to Decision, an international research consortium using artificial intelligence applications across various sectors including health care.

Source: https://www.ualberta.ca/en/folio/2025/06/getting-beyond-the-gut.html